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Profiles

Dr. Dongdong Lin

Dr. Dongdong Lin reached his PhD in Fudan University in China. Then he became an assistant professor in School of Science (Ningbo University).

Research

1. Study of the mechanism of amyloid aggregation (molecular self-assembly) and the methodology to inhibit / eliminate amyloid aggregates.
2. Fabrication of SERS substrates by using nano-fabrication methods to study the amyloid  peptides aggregates detection.

Contact

Email: lindongdong@nbu.edu.cn
TEL: 13162532518/624558(available on campus)
Address: 210 Longsai building, Ningbo University, Ningbo 315211, China.







Methods

Morphology Characterization(AFM/SEM/TEM...)


Spectral Characterization(FTIR/CD/Raman...)


Micro-nano Fabrication(EBL/Photolithography...)


Simulation(MD/FDTD...)

Studies have shown that the misfolding and abnormal aggregation of amyloid protein is one of the major pathogenic factors that related with Neurodegenerative disease. Therefore, it is important to study the mechanism of amyloid aggregation and the methodology to inhibit / eliminate amyloid aggregates.
Surface-enhanced Raman spectroscopy (SERS) is a powerful analytical tool that provides information on the molecular structure and composition of analytes through Raman scattering that is enhanced by the electromagnetic (EM) field on plasmonic substrates.There have been extensive studies on different SERS-active substrates for molecular detection with high enhancement factors. Of particular attention is SERS for ultrasensitive molecular detection in biological and biomedical applications.
In order to make the possible dectection of bio-molecules in ultra low concentration, special structures were fabricated using top-down nanofabrication approaches. Previously, we successfully fabricated large-scale ordered hexagonal-packed SiNR arrays functionalized with homogeneous AuNPs (SiNRs@AuNPs). Due to the ordered SiNR arrays and widely decorated AuNPs, we have achieved highly sensitive and reproducible SERS signals of R6G with high spatial uniformity in a large area substrate.



Get To Know Us

In recent 3 years, Dr. Lin has published a number of SCI paper, including ACS nano, Nanoscale, ACS Chemical Neuroscience, biophysical journal, et al. Google scholar website: https://scholar.google.com/citations?user=SftygNYAAAAJ&hl=en

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Selected Publications

部分发表文章

  • Paper

    "Large-Area Au-Nanoparticle-Functionalized Si Nanorod Arrays for Spatially Uniform Surface-Enhanced Raman Spectroscopy." ACS Nano 2017 11(2): 1478-1487.
  • Paper

    "Large-Area Au-Nanoparticle-Functionalized Si Nanorod Arrays for Spatially Uniform Surface-Enhanced Raman Spectroscopy." ACS Nano 2017 11(2): 1478-1487.
  • Paper

    "Highly Efficient Destruction of Amyloid-β Fibrils by Femtosecond Laser-Induced Nanoexplosion of Gold Nanorods." ACS Chemical Neuroscience 2017 7(12): 1728-1736.
  • Paper

    "Interaction Dynamics in Inhibiting the Aggregation of Aβ Peptides by SWCNTs: A Combined Experimental and Coarse-Grained Molecular Dynamic Simulation Study." ACS Chemical Neuroscience 2016 7(9): 1232-1240.
  • Paper

    "Effects of Hydroxylated Carbon Nanotubes on the Aggregation of A beta(16-22) Peptides: A Combined Simulation and Experimental Study." Biophysical Journal 2014 107(8): 1930-1938.
  • Paper

    "Investigation of the Aggregation Process of Amyloid-β-(16-22) Peptides and the Dissolution of Intermediate Aggregates." Langmuir 30(11): 3170-3175.
  • Paper

    "Fabrication of Straight Silicon Nanowires and Their Conductive Properties." Nanoscale Research Letters 2015 10(1) 325.
  • Paper

    "Laser beam controlled drug release from Ce6-gold nanorod composites in living cells: a FLIM study." Nanoscale 2015 7(6): 2433-2441.
  • Paper

    "The molecular mechanism of fullerene-inhibited aggregation of Alzheimer's beta-amyloid peptide fragment." Nanoscale 2014 6(16): 9752-9762.
  • Paper (unsubmitted)

    ...

Our Group

welcome to join us!

We hope to make some difference in our research area
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PhD candidate

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PhD student

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under graduate

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Cooperated group

Prof. Xinju Yang

Department of Physics, Fudan University.

Prof. Guanghong Wei

Department of Physics, Fudan University.

Prof. Yanwen Tan

Department of Physics, Fudan University.

Prof. Minbiao Ji

Department of Physics, Fudan University.

Prof. Yuebing Zheng

Department of Mechanical Engineering, The University of Texas at Austin.

Prof. Zuimin Jiang

Department of Physics, Fudan University.

Publication lists

Recent years

1. D. Lin, J. Lei, S. Li, G. Wei, and X. Yang, Amyloid-β fibrils dissociation by single walled carbon nanotube: A combined experimental and simulation study (submitted).

2. D. Lin, Z. Wu, S. Li, C. Ma, Z. Jiang, Z. Zhong, Y. Zheng, X. Yang, Large-area Au-nanoparticle-functionalized Si nanorod arrays for spatially uniform surface-enhanced Raman spectroscopy ACS nano, 2017, 11(2): 1478-1487. (IF 13.4)

3. D. Lin, R. He, S. Li, Y. Xu et al, Highly efficient destruction of amyloid-β fibrils by femtosecond laser-induced nano-explosion of gold nanorods ACS Chemical Neuroscience, 2016, 7 (12), pp 1728–1736. (cover article, IF 4.4)

4. D. Lin, R. Qi, S. Li, P, Li, et al, Interaction Dynamics in Inhibiting the Aggregation of Aβ Peptides by SWCNTs: A Combined Experimental and Coarse-Grained Molecular Dynamic Simulation Study ACS Chemical Neuroscience, 2016, 7, 1232-1240. (IF 4.4)

5. D. Lin, Y. Luo; S. Wu, et al, Investigation of the Aggregation Process of Amyloid-β-(16-22) Peptides and the Dissolution of Intermediate Langmuir 2014, 30, 3170-3175. (IF 4.0)

6. L. Xie, D. Lin et al, Effects of Hydroxylated Carbon Nanotubes on the Aggregation of A beta (16-22) Peptides: A Combined Simulation and Experimental Study Biophys J, 2014, 107, 1930-1938. (contributed equally, IF 3.6)

7. L. Xie, Y. Luo, D. Lin, et al, The molecular mechanism of fullerene-inhibited aggregation of Alzheimer's beta-amyloid peptide fragment Nanoscale 2014, 6, 9752-9762. (IF 7.7)

8. Y. Xu, R. He, D. Lin, et al, Laser beam controlled drug release from Ce6-gold nanorod composites in living cells: a FLIM study Nanoscale, 2015, 7, 2433-2441. (IF 7.7)

9. S. Wu, Z. Wu, D. Lin, et al, Photogenerated charges and surface potential variations investigated on single Si nanorods by electrostatic force microscopy combined with laser irradiation Nanoscale research letters, 2014, 9, 245. (IF 2.6)

10. S. Huang, H. Zhang, Z. Wu, D. Kong, D. Lin, et al, Large-area ordered P-type Si nanowire arrays as photocathode for highly efficient photoelectrochemical hydrogen generation ACS Appl Mater Interfaces, 2014, 6, 12111-12118. (IF 7.1)

11. J. Tan, D. Lin, S. Pillai, Y. Zhang, B. Li and X. Zhou, Ultrasound Effects on Assembly of Glucagon Fibrils Integr Ferroelectr, 2012, 136, 1-8.

12. X. Zhou, J. Liu, B. Li, S. Pillai, D. Lin, J. Liu and Y. Zhang, Assembly of glucagon (proto)fibrils by longitudinal addition of oligomers Nanoscale, 2011, 3, 3049-3051.

13. Y. Chen, J. Liang, T. Liu, D. Lin, Y. Wu, J. Lu, Z. Jiang. Tunneling Current Through Single InAs Nanowire at Different Temperatures[J]. Journal of Nanoscience and Nanotechnology, 2016, 16(8): 8150-8153.

14. Y. Jiang, D. Mo, X. Hu, S. Wang, Y. Chen, D. Lin, Y. Fan, X. Yang, Z. Zhong, Z. Jiang. Investigation on Ge surface diffusion via growing Ge quantum dots on top of Si pillars[J]. AIP Advances, 2016, 6(8): 085120.

15. L. Wang, T. Liu, Q. Jia, Z. Zhang, D. Lin, Y. Chen, Y. Fan, Z. Zhong, X. Yang, J. Zou, Z. Jiang. Research Update: Strain and composition effects on ferromagnetism of Mn0.05Ge0.95 quantum dots[J]. APL Mater., 2016, 4(4): 040701.

16. W. Ze, W. Shuguang, Y. Yefei, L. Tao, D. Lin, L. De-Hui, Y. Xinju, J. Zuimin, Z. Zhenyang. Promising features of low-temperature grown Ge nanostructures on Si(001) substrates[J]. Nanotechnology, 2017, 28(11): 115701.

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210 Longsai Science building, school of science, Ningbo University,
Email: lindongdong@nbu.edu.cn




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